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Are ANY of the following major criteria below met?

Prior history of gastrointestinal bleeding or gastrointestinal ulceration within the past year
Mechanical ventilation > 48 hours or acute respiratory failure requiring BIPAP/high flow nasal cannula
Significant coagulopathy that is not medication induced
(INR > 1.5, platelets < 50,000/m3, aPTT > 2x control)
Hypoperfusion defined as:
Requiring vasopressor/inotrope support
Lactic acid ≥ 2 mmol/L
Admitted due to multiple trauma (ISS ≥ 16), traumatic brain, or spinal cord injury
Intracranial hemorrhage or ischemic stroke on this admission
Admitted due to acute major burn injury (> 20% of body surface area)
Atrial fibrillation ablation procedure in the last 30 days